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Download free ebook : The Inflammasomes pdf



Book Description

The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1 and IL-
18. This finding was substantiated by the identification of several mutations in the cias1 gene, encoding the human NLRP3 protein, responsible for several autoinflammatory disorders such as the Muckle Wells syndrome. Since, the interest for this complex has constantly increased and several inflammasome complexes with different specificities have been described. These inflammasomes sense a wide variety of pathogens and danger signals and are key players in the inflammatory response. With the contributions of leading international experts in the field, this book provides an extensive overview of the current knowledge of inflammasome biology and their role in health and disease.
Contents
Molecular Definition of Inflammasomes 
Pyroptosis: A Caspase-1-Dependent Programmed Cell Death and a Barrier to Infection 
Activation of the Inflammasome by Bacterial Pathogens 
The Role of Inflammasomes in Viral Infection 
Inflammasome Activation in Response to Eukaryotic Pathogens 
Inflammasome Activation by Pathogenic Crystals and Particles 
Inflammasome Activation by Danger Signals 
Toll-Like Receptors and Inflammasomes 
Inflammasome in the Skin 
Cancer, Inflammasomes, and Adjuvanticity 
Inflammasome and Lung Pathologies 
Mechanisms of NLRP3 Inflammasome Activation in CAPS Patients 
Activation and Regulation of the NLRP3 Inflammasome 
Treatment of Inflammasome-Related Disorders 
Index

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File size : 2,48 Mb
Author (s) : Couillin Isabelle, Pétrilli Virginie, Martinon Fabio
Language : English
Page : 239
Format : PDF



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